With a little practice you can do them one-handed. It's not that tough.
But really, there's not many times when I'm brewing and I'm changing hoses around and both of my hands are not free. I just put my beer down and voila, two hands free.
I usually have both hands free, as well. The thing I noticed is that during recirculation, the connectors get hot and I have to remember to grab the hot pad before grabbing the connector!