I use to eat wheat (and other grains) but found out about some "antinutrients" (synopsis here:
http://www.marksdailyapple.com/why-grains-are-unhealthy/#axzz29h0RLBUj) that are present and did some more reading about them. Industrialized farming, with grains, is feeding a hungry world, but it's only been in the last 10,000 years ago that humans starting eating grains at all, and only in recent history that they started consuming much of them.
I understand what you mean, but I really feel that wheat is basically inedible. We can eat it, and many of us don't suffer too many ill effects, but I think the huge increase in celiac disease, IBS, etc, comes from our emphasis on the food pyramid and adding more wheat and other grains to the diet in the last 40 years. This includes corn- corn is in EVERYTHING in the grocery store, I swear! A little is probably fine, in moderation, but it's become the basis of the US diet. And that explains much of the explosion of obesity, diabetes, metabolic syndrome (prediabetes), etc.
And don't get me started on "low fat" versions of food! They replace the fat with sugar in many of those "low fat" things. I tried to buy some yogurt the other day- and it was impossible to buy more than ONE carton of yogurt with no added sugar/sucrose/splenda/saccharine.
I really feel that sugar is the enemy, but wheat is right up there too in my opinion.