Not quite sure what you are looking for (local beers not available in Boston? Rare bottles? Just good beer?) but I will try to help. I assume you are flying into PHL and driving to Lansdale, right? There are obviously LOTS of great beer options in Philly, but quite a few less in Lansdale. If you are just looking for a store, there are a couple that are likely on or near your way. Capone's is a REALLY great option.
HERE is their facebook page. nice restaurant. great tap list, and bottle shop. may be a little out of the way, but they have some real rare beers in their bottle shop. The whole foods in Plymouth meeting is another good option for takeout beer:
HERE is their beer list on Beermenus. In Lansdale there is the
Blue Dog Tavern (haven't been there in a long time, but think its still there.)
If you want a brewpub, There is
Iron Hill in North Wales (probably a 10 minute drive down 309 from Lansdale. There is a newish one in Ambler (probably a 20 minute drive from Lansdale down 309) called
Forest and Main. Good British and Belgian styles of beer and good food.
Hope that helps! As I said, there are LOTS of good options in Philly itself, but you said around Lansdale, so I tried to keep close to that. Let us know where you end up...