After pouring the DME in the pot over boiled and i lost about a cup or two of foamy liquid. Will this affect the outcome in any way? I would imagine that less fermentable could dull the flavor or cause the beer to have a lower ABV?
the potential is there, but you're talking about 2 cups out of 5 gallons. 5 gallons is 80 cups, so you've potentially lost 2.5% of your volume. But you did say that was foamy, so mostly air. I think you can assume the amount of liquid you lost was closer to 1/4 cups, or less than 1% of the total. not a significant enough factor.
RDWHAHB
I had a pretty severe boilover on my second batch of beer. First time using an outdoor propane flame (turkey fryer). Wasn't paying attention to the boil. I also had the burner set to Mach2 and it was roaring like a jet engine.
It was an Amber Ale that turned out awesome... even though the boil over was pretty bad.