My advice is meant to show the reality of running a brewpub, not as a vote against it, so don't take this wrong.
My husband and I opened a brewpub and restaurant last August. We live in a small town (25,000 pop). We have a great historic downtown building with 65 seats in the dining room, a patio, a small party room, and a bar area that seats 30. We lease our space, but did most of the renovations ourselves, along with our landlords (friends of ours). In an area similar to ours, you need capital of at least half a million, and that is if you have a wide skill set, and can do lots of things yourself. If you will be hiring it all done, add another million to that.
We did everything from recovering booths, to building a bar and backbar replicating one circa 1890, to painting 5 foot x 8 foot vintage beer posters for the artwork. We designed the menus, typeset them, along with all collateral marketing materials. We did all our own incorporation papers, as well as our application for the TTB.
You and your partner will need to be fluent in marketing, accounting, labor law and human resources, food safety, every position in the kitchen, liquor laws and bartending, etc. We have 22 employees (bartenders/servers/kitchen) to keep track of.
My husband is the manager, but spends his time filling in for kitchen staff, expediting food on weekend nights, booking parties, inventory and ordering for food and liquor, deflecting sales reps, running to the bank, running to the store, cleaning and filling kegs. I was supposed to be a part time bookkeeper

D). In reality I am the hostess on Friday and Saturday nights, fill in bartender, pastry chef, payroll processor, tax remitter, quarterly report filer, employee scheduler, ad designer, and brewmaster. I spend more time than you would ever imagine dealing with the unemployment office and dealing with employees who have garnishments out of their paychecks, which have now become my problem.
As you can see, brewing beer falls far down on our list. The brewing part of my job takes less than 10 hours per week. And it is only my job because the first couple people we had in the job didn't work out. The quality/consistency of our beer wasn't matching that of our food, which is very good. We decided we would "standardize" the process by doing it ourselves and document it, and then train someone, and remove it from our job description.
We are in our 40's, and it is hard work. It would be much easier physically when you are in your 20's, but then again, we didn't have all the skill sets we have now that are so important to keeping it all running. We also had to deal with my husband having a stroke the week before we opened. The stress of getting to the opening point is surely what caused it, and he is lucky he fully recovered. He was back 4 days later, and we opened up on time (he is a pretty tough guy).
It would be great to have employees to fill all those roles we have, but we have to keep our labor costs under 25%. We intentionally overstaffed at the beginning to keep the customer experience positive, but that drains all your profit quickly. It is a weekly balancing game, that you will get very good at if you are going to make it.
Good luck, and feel free to PM me if you have any questions.