#1) Definitely have a website and electronic order/inventory management system. Your B&M store is only open 50 hours per week. Websites collect money 24/7. See #3 -- can you make money just dealing locally? If so, online sales are icing on the cake. This is the ideal situation to be in
#2) Get a partner if you can. I don't know how much business experience you have but if you are lacking, find a local entrepreneur who can invest and help run the business-side of things. That will not only offset your risk, but you'll have some more business experience to help you get off the ground. And two people running a business is usually better than one. Yes you'll have to share profits, but you also share the risk.
#3) Run the numbers backwards, forwards, inverted, etc. Model your business and know the margins. How much do you need to sell per day, per month, per year, to make money? How much margin of error is there? If a tornado rips through the town and business stops for 30 days, can you survive? If another LHBS opens down the street and business drops 30%, whatchu gonna do? Ask all the questions and model all of the numbers. Don't forget to pay yourself. Your salary is a business expense. Don't be dumb and say "I'll just take the leftovers". Pay yourself first.
#4) Courtesy, cleanliness, & cost. I'm lucky enough to have AHS locally -- they rock the customer service a majority of the time. Their store is clean, organized, & well lit. The staff is knowledgeable, they have an amazing kit selection, their prices are competitive. This all adds up to an excellent experience. I've visited some other LBHS across Texas over the past few weeks -- they don't even compete with AHS. If your kettles on the top shelf have 1/8th inch of dust all over it -- it makes me wonder what your grain house looks like....
#5) Be a closer. You must must must must be able to close deals. Your employees must be better. Depending on your storefront, you might have a high volume of lookers. Your ability to sell 'Starter Kits' will likely make or break your local business sales. Say you have 10 lookers each day. You sell two starter kits for $150 each in January. Only one of those guys takes on the hobby and spends $100/month. You turned 10 lookers into $1500 bucks for the year. Same situation but this time you sell 3x starters and convert two by offering free weekend classes w. the starter kit which makes them make better brewers and more likely to keep the hobby. Instead of $1500 per 10 lookers, you're getting $2850. +90% revenue just by offering free weekend classes with your starter kits. Just an example situation with theoretical numbers but you get the idea.....