depending on your region. Hops grew naturally in upper northern U.S. and Canada. I believe these were mostly similar to or actually cluster hops.
as far as genetics...leave that to the professional horticulturalists producing different varieties.
I have seen wild hops and had some huge cones (not many) but then again this was down river from a couple breweries in the early 1900s. I have to assume the rubbish from the bales of hops propagated down stream.