Twss
I think it's well worth it for homebrews to at least once try and eliminate HSA right from the start of your brew day with your mash in water. You may be surprised as I was.
I think it definitely can't hurt to try to eliminate O2 from every part of the brewing process except for pitching time.
In a homebrew setting, you would have to be very sloppy for HSA to matter. In fact, total lack of HSA has been shown to cause haze and colloidal instability. You will never get rid of all HSA, but as long as you are not going our of your way to splash/aerate your hot wort you should be fine.
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