Great Notion, Breakside, Ex Novo, Hair of the Dog, are all pretty cool.
Touristy breweries are all located on Flanders on the Westside. - Rouge, 10 Barrel, Deschutes etc.
Check out pFriem's Pilsner. The brewery is outside of Portland, but it is easy to find all over Portland. Block 15 is an Oregon brewery, but not Portland. Try anything you can find from them in Portland- easy to find in bottle shops.
Other tips: Don't lick the stripper poles, and Salmon Safe Hop IPA pairs well with a Salmon Dinner.