Antibiotic added to wort?

[day_trippr]

Isn't this how The Blob got started?

 

[Silver_Is_Money]

Whenever taking Doxy it is advised to stay away from direct sunlight, as it sensitizes the skin and can cause sunburns or rashes. Doxy past its due date can cause renal failure.

 

[TwistedGray]

In the reverse, actually I have absolutely no idea if this is in reverse, what about adding probiotics? I find that taking probiotics helps with my guts when I do drink beer. Now I'm usually taking the probiotics early in the morning when I'm hopefully not drinking beer, but I don't know if it would have an impact on when I take it. So I'm wondering if I can just add probiotic to the beer either in the secondary or before bottling?

 

[RPh_Guy]

what about adding probiotics?

Yes, I make and drink sour beer

 

[Proteinguy1995]

@Dland - Thanks for the response, I for sure would not let anyone drink it till I had one myself. I just found some literature stating its 95% stable in acidic medium after 2 weeks, they didn't look far after.

@Silver_Is_Money

Whenever taking Doxy it is advised to stay away from direct sunlight, as it sensitizes the skin and can cause sunburns or rashes. Doxy past its due date can cause renal failure.

I was taking doxycycline, 100mg a day for 2 months. I had no problems with my skin, I also knew about the side effects when i was taking the drug?. There is about 2mg/beer, if all of it is solubilized and stays within the wort, which is unlikely. It's known to chelate divalent/trivalent cations (which wort has plenty of) and precipitate.
It's also not expired, and I doubt most has broken down in solution as of yet.
Can you post your source for the renal failure claim? If this is true, it is probably in circumstances where the patient has impaired kidney function, and has been taking the medication for an extended period of time. Don't forget the standard tablet dosage is 100mg.
https://www.accessdata.fda.gov/drugsatfda_docs/label/2008/050795s005lbl.pdf
https://pdf.hres.ca/dpd_pm/00042598.PDF
Both FDA guidelines and Teva guidelines (the brand of doxycycline i have) say nothing of this.
Updated EUA patient fact sheet by the fda (in case of anthrax breakout mind you):
https://www.fda.gov/downloads/emergencypreparedness/counterterrorism/ucm265824.pdf
* If you have received doxycycline with an expired date on the package, FDA has authorized its use. Testing of the medicine found it is safe to use past the expiration date.
-also says stable in water at room temperature for 14 days.

I appreciate the concern @Silver_Is_Money, but talking to many of my colleagues today (many of whom have PhD's in biochemistry) seem to think there should be nothing wrong, as I initially thought. I haven't spoken with any medical doctors, but I think a pharmacologist, med chemist, or biochemist would be better suited to handle the type of question I posed.

I'll definitely be keeping up with the thread, and give you guys an update after I try one (if the beer is not horrendously off flavored that is)

 

[Proteinguy1995]

In the reverse, actually I have absolutely no idea if this is in reverse, what about adding probiotics? I find that taking probiotics helps with my guts when I do drink beer. Now I'm usually taking the probiotics early in the morning when I'm hopefully not drinking beer, but I don't know if it would have an impact on when I take it. So I'm wondering if I can just add probiotic to the beer either in the secondary or before bottling?

I imagine it would be ok as long as the probiotic can survive the conditions of the beer. It would also be tricky if you are performing natural carbonation with sugar. The probiotic bacteria would likely use some of that sugar, adding off flavours from unwanted metabolic products. I'm sure someone has done it. I also know that some bacteria are encourged in some types of beer to produce the flavour (more sour?).
A quick google search yielded this:
Developing sufficient counts of in beer is a challenging feat as beers contain hop acids that prevent the growth and survival of probiotics.
Try it with a low IBU beer? Or like a barley wine almost? More wheat the better!

 

[RPh_Guy]

I appreciate the concern @Silver_Is_Money, but talking to many of my colleagues today (many of whom have PhD's in biochemistry) seem to think there should be nothing wrong, as I initially thought. I haven't spoken with any medical doctors, but I think a pharmacologist, med chemist, or biochemist would be better suited to handle the type of question I posed.

So, you're driving along some back road and you see a large lake that appears to be frozen. You think to yourself, "wow, that would be fun to drive across." You don't really have a good reason to do it and clearly no one else has driven across the ice.
Then another thought crosses your mind, "maybe it's not safe. I should ask if I can do this."

You call your favorite mechanic, who verifies that yes, your vehicle is functional and can drive across a frozen lake.

Next you call a meteorologist, who tells you that it is currently just below freezing temperature, allowing ice to form.

Finally you call your friend who's a physicist with a PhD. She tells you that ice is a solid and your vehicle is able to drive across a solid surface.

Now let's test your real-world critical thinking skills. Up 'til now, none of these highly qualified professionals related to this task have told you that the lake is unsafe to cross, and you have some pretty reliable facts.
Do you drive across it?


....
What you don't know can't hurt you? Wrong.

With no published safety data from drinking low dose antibiotics put through a beer fermentation, the answer is pretty clear. 1. You should have finished taking your prescription and 2. Adding it to beer and drinking such beer is a plainly terrible idea with questionable safety.

Sorry for all the nonsense

Happy to help!