Not been to manchester much recently apart from a weekend a month or two ago, so these links might help you, although ratebeer will obviously rate new stuff better even if it isn't and will rate barrs/pubs with more taps as better even if they aren't, but should be a good guide
https://www.ratebeer.com/beermap?p=0&z=11<=5348139&ln=-223318
This shows some (most?) of the breweries in the area, so keep an eye out for those local brews. Most breweries in the uk aren't set up for visits like they are in the us, they tend to just supply the trade
http://www.quaffale.org.uk/php/showmap.php
The family run traditional breweries in/around manchester are Holts, Hydes, JW Lees and Robinsons. You may or may not like these breweries beers, I dislike Robinsons a lot for example with the exception of one or two of their beers. Holts make a nice mild iirc.. They should have links to their tied pubs on their websites
Do check out the Marble Arch pub and drink some marble beers - I think they are back on form after a bit of a dip
For newer breweries, everyone seems to rate Cloudwater really high, unlike most new breweries they had a lot of money behind them and have a very good cultivated image. Some of their beers are very very good so worth keeping an eye out for them
If you like Tankanova Pilsner Urquell, then make sure you go to Albert's Schloss, it's a great new bar that I went into on my last visit
