I think most people are physically tired at the end of the brew day because it's cheaper to be tired than to eliminate most of the physical work involved with brewing. The pros will have very large access ports and bottom drains so that they can automate the heavy chores, but that sort of thing doesn't make much sense at the home scale.
Lifting Water and Wort - Using pumps and plumbing house water pressure into the brew area will help with this considerably, and is low cost (RV water hose, 24v DC pumps, etc). Using water pressure and a 3-tier system would work too, but has other drawbacks.
Lifting Hardware - If you're using kegs the weight of those suckers makes everything a chore. Bayou kettles are light and reasonably durable.
Lifting Ingredients - Single tier is the way to go, but again would require some form of pumping to avoid lifting water and wort.
Moving Finished Wort - If you can run from your boil kettle right into the fermentation chamber then you're saving a bunch of lifting and bending.
Dumping Ingredients - Building in a tippy-dump as @Yooper suggested is a good way to save some back pain. I've also heard of people using a shop-vac on wheels to suck the mash tun clean. Be sure to have nice wheels on whatever you're dumping into, and somewhere low in the yard to roll to.
Cleaning - This one can be the worst since it's more difficult to automate. Spike just did a how-to video on their 3V system that includes a section on cleaning near the end:
https://spikebrewing.com/collections/spike-systems In truth, that video does a pretty good job showing how to do a full brew with minimal work. Long handled scrub brushes can help minimize the leaning and bending, even with a CIP spray ball it's tough to avoid all of the scrubbing. Probably the most important is having a good drain plan. If you're draining into buckets and moving those to the back yard to dump, you're working pretty hard by the end of the day.
Disassembly and Storage - This is an area where you can save work with organization. If your gear can stay mostly set up then you don't have nearly as much work. Nice hooks to drain the hoses will help, and spots to keep all the tools.