There is St. Arnolds Brewery near the Galleria area. I know at one point they were talking about opening a brewpub.
The only other one I'm aware of in the Houston area is Two Rows (in Rice Villiage), although I've never been there, so I can't give you much in the way of reviews, etc...
You're pretty much in BMC land, so brewpubs/micros/craft beers are difficult to come by. There are some good pubs, but not much for brewpubs or the like.