I actually primarily do 2.5gal batches. I had efficiency issues when I first started with my 10gal Igloo mash tun, so I eventually moved to a 5gal and have been very happy with it. I don't know if my issues were with the mash tun itself or other parts of my process, but I can tell you that doing a beer thats less than OG1.050 with a full size mash tun is kind of a *****.
You could just pitch a single vial/smack pack and the rate would be correct for most beers, but I usually like doing a pint starter about a day beforehand to wake the yeast up and be sure I have as close to 100% viability as possible.