We use sanitary/tri-clover/quick clamp fittings on all of our equipment at the brewery and they are a pain when you first start using them, but you'll quickly learn all kinds of tricks and flips that make connecting them quite easy. If you can do it with one hand, then you're a better man than me 'Topia! I usually need one hand to hold the hose against the fitting and one to flip the clamp on. Then, one hand to hold the clamp closed and one to tighten the screw.
You can disconnect them with one hand, granted, unless you have something like caustic in the line that you don't want to splash on anything...
When we CIP our tanks, our process has us connecting/disconnecting the hoses over and over again for running the tanks and rinsing and it becomes quite the good practice drill. If you don't have it down, you will soon!
I've seen even smaller fittings as well, maybe 3/4 to 1 inch? May make more sense in some locations.
Anyway, don't fear the clamps!

You can disconnect them with one hand, granted, unless you have something like caustic in the line that you don't want to splash on anything...
When we CIP our tanks, our process has us connecting/disconnecting the hoses over and over again for running the tanks and rinsing and it becomes quite the good practice drill. If you don't have it down, you will soon!
I've seen even smaller fittings as well, maybe 3/4 to 1 inch? May make more sense in some locations.
Anyway, don't fear the clamps!
