Holding your mash 30-45 mins between 140 - 149 will produce very fermentable sugars which will result in a lighter body, dry beer. 150- 158 will produce less fermentable sugars and result in a fuller body with some residual sweetness. If you want lighter body, drier, higher alcohol, mash longer in the 140-149 range, if you want the opposite, spend more time in the 150-158 range. Or you can keep it at 152 for 60-75 mins and be somewhere in between. Your choice.
If you do a targeted 2-step mash, you can probably get away with 60 mins total time for both. If you do a single step mash, then I'd go for 75 mins since both enzymes are not in their 'ideal' range and will take longer to do full conversion.
I wouldn't over do the mash time though, you may end up pulling out tannins and other off flavors from the beer. Most of the starch will be converted to their various sugars after about 60-75 mins total time. You can heat to 168 to get the wort to drain better, but never go higher than that or you will start pulling tannins out of the grains.
All of this assumes that the PH of your mash is in the 5.0-5.6 range-which it usually will be. (Unless you are brewing a stout with soft water, or a pilsner with hard water).
I personally consider the mash timer as ticking when I'm in the mash temp range. Even if I'm heating through.