Using a slow cooker for mashing would be kind of like using a steam jacketed mash tun, in that the temperatures would vary from the centers to the sides/bottom. If I were going to try this, I would...
- use the cooker on its very lowest setting -AND-
- use an external temperature controller, with the probe in a thermowell in the mash
I have actually sort of done the above with mini-mash experiments, where the "mash jars" were submerged in water, whose temp was controlled the way I described. But in my case, the water around the jars served to buffer the "direct" heat from the cooker.
In a steam jacketed mash tun (without stirring), the liquid near the sides can literally boil, while the middle of the mash is at say, 150F. So these tuns normally have a way to stir the mash. I don't think a slow cooker heating on its lowest setting would be anywhere near that problematic, but I do think there is the possibility of uneven mash temps throughout the mash.