uhlee, thanks for the good suggestions!
Here's what's happening at my house right now:
Rubbed a 1/2 brisket with a mixture of Turbinado sugar, onion powder, salt, pepper, and Emeril's Essence.
Dumped a bottle of Sierra Nevada Stout into about 1/2 cup the leftover rub. Added cider vinegar until it looked and smelled good (maybe 8 oz).
Mopped the brisket with the stout sauce and began smoking at 250 with a mixture of 2/3 mesquite chips and 1/3 hickory.
Plan is to turn/mop every two hours.
I'll let you know how it comes out.