If you're going for a limited run, such as 1 or 2 seasons and no more, then I say yes. I've worked on pilots for proposed shows, one was to be a partially comedic cooking show following a guy who, every time he goes and hangs out or on a date, ends up cooking something with explicit instructions...and I gotta say, the food was marvellous! Another was a comedy about a gym and the various absurtities that really are common in gyms (though maybe stretched a bit) such as the guys who spend hours on the bicycle with a load of junk-food watching movies on the screens on the handlebars and whatnot... This was over 10 years ago, and it was still pretty much the custom to pitch a show with the expectation it would run continuously for years. In more recent times, there is an ever increasing number of mini-series, and with so singular a centerpiece as the founding and operation of a microbrew, I'd write it out and pitch it with the stated intent of no more than a season or two.
As viewer, I am far more attracted to a show if it looks like they can fully cover thier premise and wrap it up without struggling to concoct ever more ludicrous stories solely for the sake of keeping it running.
I'd definitely give such a show a try, but only if I knew it had a forseeable closure.