I switched from cam-lock to the ball-lock QD fittings soon after I started brewing again last year. Just too much of a PITA to connect up the cam-locks. With the ball-lock style, I can make the connection with one hand.
I have male fittings on all kettle (or stationary items as already mentioned) and female on all the hoses. Hose fittings are also the full bore size, so 5/8" barbs to get an actual 1/2" ID on the fitting. My kettles have 1-1/2" TC fittings on them, so I just connect the matching TC to QC fittings as needed. Plate chiller has a male QD fitting on the wort in and a TC fitting on the wort out. That allows me to place the oxygen infusion setup onto the plate chiller and not have it move on me (rotate). Pump heads are center inlet, but also TC connections, so no NPT adapters needed.
NOT having any NPT fittings on almost everything (except the wort in on the plate chiller) is a HUGE plus IMO. I have butterfly valves everywhere except the MT recirculation inlet fitting (ball valve there) and the plate chiller outlet to control chilling temperature. All valves are TC connections. Even with the higher cost of the TC fittings, the ease of disassembly more than makes it worth it (IMO).
I also ditched worm clamps ages ago. With the oversized barbs on the female/hose fittings, you don't need them. On all my keg lines I have oetiker clamps since they simply don't leak, ever. I've had nothing but problems anytime I've tried using worm clamps. Even the "butterfly" style (on the glycol chiller lines, before going to oetiker clamps there).
I also make it a point to have reserve 1/2" ID tubing on hand in case I either need to make a different length line, or want to replace what's already in use. Once they reach a certain level of discoloration, I 'retire' the old piece. I do try a PBW soak before that though. But with the barb size I'm using, changing pieces is actually pretty easy.