I've done a double batch with the partigyle method and by doing a large 8 gallon batch and splitting it into two batches with different yeasts. I have only one small fermentation fridge though so that was a challenge. I ended up fermenting in two corneys b/c they both fit in my fridge that way. I removed the beer-out nut and assembly and jammed an airlock in there. Worked perfectly and I was able to produce double the beer for roughly the same work/effort.
Partigyle pros - made two completely different beers, can be creative with the recipes
Partigyle cons - fermented two different beers/yeasts at the same temps, brew day took longer because I needed a seperate boil for each beer
Large batch pros - same amount of worrk/effort but end up with more beer, get to isolate what yeast really contributes to a beer (same base recipe but use different yeasts)
Large batch cons - fermented two different yeasts at the same temps, had to alter my tried and true 5 gallon recipes for the larger batch size, have a large quantity of a very similar tasting beer