What are you going to do Mr. Rage?
I'm going all stainless hard plumbed with Swagelok connections. I've already sunk several Benjamins into compression fittings and solenoids, so it's a done deal now!
I've done hard plumbed copper and flexible tubing with disconnects. I started with hard plumbing, which worked well, but sometimes you could get liquid from Point A to Point B very easily, though that was mostly a design issue. I originally liked the tubing/QDs, but over time it's become more annoying to always be flipping hoses around and having to sanitize them and then after I sanitize them, trying to remember if I sanitized hose A, B or C. It's just a bit of an organizational annoyance. Though, I'll admit, most things are an organizational annoyance for me.
Also, the nice thing about the Swagelok fittings is that you can get swage-to-barb connectors. If you have an emergency, you can just pop off the hard piping and use the same compression fitting to pop on a flex hose.
With my new hard piped system, I'm pretty much going to have every possible transfer combination plumbed in and it'll all be CIP. I'm with CB, I want my brew session to be sitting in a chair flipping switches, or better yet, sitting in a chair letting a controller flip switches for me.