After further discussion, and not giving ***** about inclement weather and spending extra on another hotel...
Napa tomorrow, then beer rounds Wednesday.
Any suggestions on hotels in the beer areas are welcome.
Thanks everyone for all of your insight, it really is helpful and appreciated.
Napa is not super close to Russian River, Lagunitas, or any of the other Sonoma county spots. If your goal is to hit those places, I'd go straight there and skip Napa. If you want to spend time in Napa, the Hilton Garden Inn is solid/reasonably priced and just north of downtown. The Bounty Hunter is decent for BBQ and drinks.
If you're in Sonoma, decide where you want to go. You can have a full day between Russian River and Lagunitas. If you're like me, you'll probably not be able to drive after Russian River and Lagunitas back-to-back, especially if you plan on hitting a third spot like Hopmunk or something else up there. Find a DD or use Uber or cabs and make Petaluma or Santa Rosa your "home base". If you hit Russian River first, then go south to Lagunitas, and want to spend the night, check out the Sheraton Petaluma or Sonoma Creek Inn.
Tons of alcohol options around Sonoma county.
From there, it's an easy trip on Wednesday to the city for Cellarmaker (they open at noon on Wednesday). I recommend grabbing a couple half-pints, grabbing a growler (or two) and doing lunch at the food trucks at SOMA Streat Food Park, or hitting one of the local famous burrito joints (ask
Ryan_G for recs).
After lunch, it'll take a couple hours to drive down to Sante. Go 280, it's a great drive. Watch yourself over 17, it's sketchy for first-timers. Sante will be open at Noon this Wednesday if you want to get their earlier and skip the city festivities.
I like to go to Sante, have some beers, walk around Capitola or the beach, and grab dinner at Aptos BBQ. Stay a while, drink more local beer (tons of local taps) and check out the live music. Aptos is more expensive for hotels, but you can go back to Santa Cruz for the evening. Mission Inn is nice and has a hot tub for closer to $100. The Boardwalk and Wharf can be fun places at night too.
Good luck and let us know what you decide.