Room temp is not harmful to yeast. Yeast will remain viable for longer if kept cold, but they are not actually harmed by being at room temp, they just go through their normal life cycle at a slightly faster rate the warmer it is up to about 90F, which is when you might actually start to harm them due to heat.
Activating the pack is as much a marketing gimmick as anything else. Nothing particularly special happens due to "activation."