Most ales use straight CO2 for carb and serve. Porters, stouts, and big beers (old ales, barleywine, wee heavy, etc.) can benefit from nitro/co2 mixes. Beers are different in the glass depending on the serving gas.
I'm using CO2 for my pale ales (currently at least) and nitro mix for the stouts and such (three stouts and an old ale on tap). The brews on nitro mix are using stout taps to dispense. I'm considering putting the pale ales on nitro mix as well. Just haven't done so yet. I might brew a large enough batch at one point to serve the same brew under both.
BTW, you can typically get the nitro mix in two different versions. 75/25 (75% nitrogen) and 60/40. I'm using the 75/25 mix at this time. I am planning to change my beer lines, making the ones on nitro mix longer due to the higher pressure level. That's somethin else you'll need to keep in mind if you go with the nitro mix.
Bottom line, cheapest mode is just CO2.