You mean you're using the blowoff tube??
Replace that fitting with a TC cap and then proceed. IMO, this should be pretty evident. If you don't have a 'spare' 1-1/2" TC cap, then get [at least] one before you proceed.
I've been fermenting under pressure with my conical fermenters from the start (was doing it before I got the conicals). I know the CF10's come with the blowoff fitting, but I've not used the ones that came with the order. At least not for that (might have them on a couple of hoses in the brewing system).
Are you planning to carbonate in conical as well? I've been doing that since getting these with the Spike carbonation stone item. Works great to get solid carbonation levels in 2-3 days (after reaching the correct temperature).