Autolysis rarely occurs in a homebrewing setup -- it is much more an issue in professional brewing. You should always wait until fermentation is done before racking to a secondary vessel (if you even need to -- should generally only be done for extended aging). Take a gravity sample, if it stays steady as Lcoron4 said, you're fermentation is done. I generally wait a few days after fermentation has ended to allow the yeast to clean up any byproducts.
Honestly, patience will help a lot with your beers. If you're not in a hurry for a special occasion, try throwing your fermenter in a closet for 3-4 weeks before doing anything to it. You'll definitely notice an improvement in your beers.