Definitely hit Wicked Weed. Their food and beer are both outstanding. Asheville Brewing Company is also pretty solid. I'm not a big Highland fan, but a lot of people enjoy their beer and they've been in the business for a long time now. The Thirsty Monk is a really cool beer bar. If you're pressed for time, I'd say Lexington Ave Brewing is one you could skip. Not trying to hate - just an opinion. There are about a dozen more breweries I haven't mentioned. These are just off the top of my head.
Have fun. It's a great town to hang out in. Also - if you like a good burrito, check out Mamacita's. It's near Wicked Weed.
Cheers.