I haven't been to these places, but my list for driving up the coast based on brewers I love...I plotted a trip even! I'll go north to south in CA since Oregon and WA are pretty well covered here....
Lost Coast Brewing in Eureka, CA
North Coast Brewing, Fort Bragg, CA
Russian River Brewing, Santa Rosa, CA
Lagunitas Brewing, Petaluma, CA
Anchor Brewing Co, San Francisco, CA
21st Amendment Brewery, San Francisco, CA
http://bit.ly/aD9iQ1
Other big guys to consider are Sierra Nevada Brewing in Chico (I hear the facility is kickass, but it's 100mi inland from the coast breweries) and Firestone Walker in Paso Robles (a hundred miles or so farther south than Monterey)
I plan on driving this trip in reverse up to Portland one of these days. One day
Edit: I see you said you're driving down the 5, and obviously the route I posted goes a different route. The 5 will take you near Chico for Sierra Nevada, but IMO Russian River is worth going out of the way for...even if you have to backtrack from San Fran after you take the 5 down. You can see what the fuss is about on Pliny the Elder and their sours are amazing. Lagunitas which is about halfway between both makes a ton of great beer too.