KC is pretty spread out. That being said, there are a couple of pretty decent chain liquor stores here. Lukas Liquors, both on the south side of KC and Gomer's. There are several Gomer's on the south side and one on the north side.
The beer selection in KC is pretty good. There are a few beers that are brewed local that you can find on the shelves here. Boulevard, 75th Street and Doodle Brewing. Doodle is fairly new and the only thing they have out now is a Belgian but, it's pretty good! 75th Street beers seem kinda hit and miss as far as availability. You'll find Boulevard pretty much everywhere you go. Any of their 'smoke stack series' are great. If you like IPA's, you'll have to find their 'Double-Wide IPA', fantastic stuff!
Really, other than that, you'll probably find most of the same stuff here that you would find in SD.