My top recs for breweries: Lucky Lab (NW), Amnesia, Widmer Gasthaus, Deschutes Pub, Bridgeport Brewery (NW), Laurelwood (NW/NE - the NE one is better), the Upright Brewing tasting room (NE), Full Sail Pilsner room (SW), Hopworks (SE), McMenamin's Kennedy School (NE - or grand lodge, or edgefield), Racoon Lodge (Beaverton - Cascade Brewing, great sours), New Old Lompoc (NW or N)
pubs: Horse brass (SE), belmont station (SE),green dragon (SE),henry's on 12th (NW), Bailey's Taproom (SW), Saraveza (N), Victory (SE), moon & sixpence (NE)
If I were you, I would either stay downtown (ace hotel,nines, corporate, etc), or inner southeast at The Jupiter Hotel, or in NW at the Inn at Northrup Station (I had a good experience there while my house was being worked on).
no matter how you do it, you'll have a hard time avoiding good beer (and food). feb is pretty cold so bring some warm stuff (although nothing like chicago haha).