ditto. the ambient oxygen is a benefit when fermentation starts.
if you're worried about it from a sanitation aspect, then what you can do is clean the hell out of it, and then hit it with sanitizer. then open the bottom port, and blow compressed air through a sterile filter into a top port. all the old air and leftover sanitizer should come out the bottom.
i think thats a bit overkill, but if you are brewing outside or in a dirty/dusty/etc type place then it might make more sense. if you have an oilless compressor you're good to go, if its an oiled type, make sure you have good water/oil filter on the compressor or you'll dirty/clog the sterile filter.