For home defense, get a semiautomatic shotgun, bird shot for the first round to scare said intruders, buck shot for the rest ... With a shotgun it is point and shoot, even if you're panicked you'll be okay, plus shooting clay targets flying through the sky is FUN!!! For the range, get a .22 caliber, you can't beat the price of ammo. If you want something loud, a hand cannon, then a .40, .44, or .45 caliber should do the trick. I've had lots of fun with my buddies 9mm, which is very near a .38 caliber. The ammo for his gun is much cheaper than for my .40 cal. S&W eating glock 22. Like Neunelfer said go to a range, rent a few guns and see what feels good for you. What ever you decide on lock it up and keep it way from children, my glock came with a lock and a warning that it attracts children.