pricelessbrewing
Brewer's Friend Software Manager
I don't like DIPAs, but a small part of me just wants to brew something theoretically extreme on the IBUs. Even test one at 120 vs 400, or something like that. Why can't brulosophy do one of those? I'm sure he could get the hops donated for it.
iso acids have a solubility limit that isn't accounted for by the tinseth formula. Moreover iso acids degrade throughout extended boil. Some of them are lost after the boil, to trub. Some are lost after fermentation.
Besides the science above it's often attributed that we can't taste above 70 Ibu. I doubt there would be any significant difference. I'm sure that it's somewhere on Marshalls extensive "to do" list though.