Even with a new O2 tank, the airflow is greatly reduced after 20 batches or so.
I haven't touched it with my fingers to avoid getting oils on it. Obviously it's very porous, so I want to stay away from any soaps or cleansers that could get into my beer.
It's recommended to boil it. I do it for 15 to 20 minutes. And since mine is mounted pretty tightly on a wand I just fill a pot with water, get it boiling and then just balance it in the water for 15 minutes or so.
Soak it in alcohol. I have been using that same SS diffuser for more than five years without problems. I rinse it well after use and occasionally soak it in pure alcohol. Never had any clogging problems whatsoever.