Ok, so I've done two batches with this method (NE IPA and DIPA) and think I can make a small review.
Overall this method works perfectly for me since it simplifies a lot of things – fermentation, dry hopping and serving are all done from the one vessel. The total price tag is about $100 for a keg and $50 for CBDS (with a filter), that's why I could easily recommend trying it out.
Regarding any off-flavors – after 3 days cold crashing the beer was great. The reason why I've said 3 days is that I did notice strange grassiness after 1 day in my first batch and I'd say something between yeastiness and astringency in the last. Nevertheless, I think it was rather because of me and not because of the method. Anyway, it was all gone after 3 days cold crash and the DIPA is still great after about a week in the kegerator.
Also, I used the no blow-off method first time (with the spending valve) because it was 3g batch, the second time I brewed 4.5g + 1L starter batch and I just removed the gas post (leaving the dip tub inside) and put the 1/2" hose using the hose clamp to secure it. Both methods worked pretty well. I did use FermCap, though, so the blow-off losses were minimal (about a few cups).
A few other things, during dry-hops addition I connected a gas line and run about 3-5 psi to prevent any oxygenation as it was recommended earlier in this thread. That seemed to work well, at least I feel better doing that
I also noticed that I saved a lot of CO2 since I don't need to purge keg for closed transfer and I can slightly naturally carbonate once the fermentation is finished.
Regarding pressurized fermentation, you need to take into account that the higher the pressure is the slower the fermentation (the Tilt's guys have an experiment on this).
I think that all I can share for now but overall I probably won't get back to 2 or 3 vessels ever again.