Probably won't have the power to keep up with the heat draw down when you run the HERMS. Perhaps if it was a humongous crock pot or a very small batch size you could get it to work, but with only 110 v input I just don't see it generating enough heat fast enough. I did experiment with mashing directly in a crock pot. I wanted to see if I could make some starter wort quickly. It worked, but I deemed it not worth the hassle in the end. A small cooler would have probably been a better way to go. I've abandoned that approach and now I'm planning to just make a larger batch of wort and can it.