Cigar City. By FAR my favorite brewery in the country. Go there. I know they are having some special event one day this week though... not sure which day.
Try their Humidor IPA, Oatmeal Raisin Cookie Brown, Tocobaga Red, 110K, Maduro Brown, and anything else.
Only beer I have ever had from there that I did not feel was phenomenal was the Guava Grove.
Man I miss Cigar City. But I have an acquaintance mailing me some Active Yeast Samples for analysis that happen to have CC's logo on them.
Tampa Bay Brewing Co. in Ybor has some good beers too.
For food though, I would say The Columbia is a great "Traditional Tampa" Cuban restaurant. The Colonade is great for seafood. If you want to spend some money, Bern's Steakhouse is probably one of the best steakhouses in the world (they do have one of the biggest wine collections too, if you're into that). For Mexican food, The Tacobus can't be beat.
I lived in Tampa for 15 years, so feel free to PM me if you have any questions. Are you staying in North or South Tampa?