Sharp Edge on Rt.60 is one of my favorite places for good beer. If your going to be near Heinz Field (NorthSide) this week end, there is a Rib Cook Off and Free Concerts (Clarks this evening).
I would second Fatheads. The brewpub is located out here in North Olmsted and they make some pretty good beers.
Headhunter IPA is great if you're into west coast style ipas. I haven't tried all of their beers, but I have no complaints about the 7 or so that I have tried.
No idea how the food is in Pittsburgh but the stuff here was great.
Third on Fatheads, my favorite place to eat in Pittsburgh. Sharp Edge, of which there are 3-4 locations around Pburgh is also great. East End is the trendy micro in town but there is also Penn and Church which have restaurants at their brewing locations.