I'm no botanist, but my hops have the random mutant leaf as well. I never bother with any sprays and the plants are very strong and healthy. They seem to be quite resilient! Although my centennials are definitely the slowest and most troublesome of the 3 varieties...
That looks like iron deficiency, applying any fertilizer with iron in it will fix that.
wfowlks...your comment about all the rain made me think that one more thing to rule out is whether or not your pot is draining well. I couldn't tell from your comments if the hops are growing in a pot or not but, if they are, double check that water runs out the bottom after watering. A water-logged plant is no good.
wfowlks said:Hawg did the miracle gro hit the leaves, I just try to water the base, because you look like you have some well colored leaves, and the phosphorous may burn the leaves if applied in the middle of the day or in the sun
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