Alcohol skews the reading on the refractometer. They're great for measuring the OG (in Brix) for non-fermented wort, but once alcohol is in there, the readings get miscalculated. You can use a "refractometer correction table" like they have in Beersmith, but even that isn't 100% accurate. I use a refractometer for gravity readings for wort, but after fermentation has begin (with beer or wine), I use a hydrometer.