It is usually sufficient (and very important) that you thoroughly rinse off buffers while calibrating and sample when measuring so that one buffer doesn't contaminate the other, so that a buffer doesn't contaminate a sample, so that one sample does not contaminate another etc. A squirt of DI water from a wash bottle is sufficient for this. The theory is that with time protein from wort or beer will eventually build up on the sense bulb. That would be the time to call in Zymit.