Safety[edit]Steviol and rebaudioside A are not mutagenic at doses and routes of administration at which humans are exposed to them.[42][43][44] Two 2010 review studies found no health concerns with stevia or its sweetening extracts.[45][46]
The WHO's Joint Experts Committee on Food Additives has approved, based on long-term studies, an acceptable daily intake of steviol glycoside of up to 4 milligrams per kilogram of body weight.[47]
While the FDA does not consider whole-leaf Stevia or crude Stevia extracts to be "generally recognized as safe" ("GRAS") food additives,[48] several companies have submitted notices to the FDA that they consider specific rebaudiosides to be GRAS for use as food additives, and have had these notices accepted by the FDA.[49]
The European Food Safety Authority evaluated the safety of steviol glycosides, extracted from the leaves of the Stevia rebaudiana Bertoni plant, as sweetener and expressed its opinion on 10 March 2010. The Authority established an Acceptable Daily Intake (ADI) for steviol glycosides, expressed as steviol equivalents, of 4 mg/kg bodyweight/day. On 11 November 2011, the European Commission allowed the usage of steviol glycosides as a food additive, establishing maximum content levels for different types of foods and beverages.[50]
Potential health effects[edit]A 2009 review study found that stevioside and related compounds may have anti-hyperglycemic, anti-hypertensive, anti-inflammatory, anti-tumor, anti-diarrheal, diuretic, and immunomodulatory actions.[51] A 2011 review found that that use of stevia sweeteners as replacements for sugar would likely benefit diabetic patients.[45] Furthermore, the report noted "stevioside has shown some evidence of pharmacological effects in patients with hypertension or with diabetes mellitus type 2,"[42] but concluded further study was required to determine proper dosage.