Strictly speaking, what most homebrewers who use a secondary do isn't a secondary fermentation, but a bright rest - the first fermentation is still ongoing, but they are removing it from the yeast cake to clarify and avoid yeast autolysis. A real secondary fermentation would involve adding either additional fermentables, or a separate microbiota pitch (or both).
Here's the crux of the issue: yeast autolysis. This is a serious issue for commercial brewers, especially the BMCs, because of the batch size. The larger the batch, the more the yeast cake gets compressed, especially in conical fermenter. However, since one of the purposes of a conical is to allow you to draw off the yeast cake, this rarely becomes an issue unless the brewers are really sloppy. In any case, any batch size less than (for sake of argument, as I don't know the actual size) 10 barrels isn't likely to compress the yeast enough to cause a problem. Compression autolysis is rarely a factor for craft brewers, and pretty much never comes up for homebrewers.
Most lager brewers will lager in a separate bright tank, more to free up the fermenter than anything else. This lets the beer clarify off of the yeast cake while lagering.
Yeast autolysis used to be a big issue for homebrewers, but for a completely different reason. Up until the late 1990s, the dry yeast most homebrewers had access to was of poor quality at best - it wasn't uncommon for baking yeast to get repackaged as brewer's yeast, and even when a real brewing strain was used, the preparation and handling of the yeast was often sub-par. A large part of the reason liquid yeast became popular when it first appeared in 1991 was that it was generally much better quality yeast, and the yeast health was better from more careful handling.
This isn't nearly as much of problem today, however - dry yeast manufacturers for homebrewing have really cleaned up their act in the past twenty years, and the problem of yeast health is almost gone today. Unless you have the misfortune of getting some ancient yeast packet with a Coopers' kit that has been sitting on the shelf for five years, or you let your fermentation get to temperatures above 90 degrees F for an extended period, you should be able to keep your beer on the yeast cake for a month or more with no measurable risk of the yeast autolyzing.