My only concern is that on the bottom 1/3 or so of the vine, all the leaves are turning yellow and curling up. I'm not sure whats going on, it gets plenty of water...I dunno. I hope it doesn't continue up the vine and take out the cones!
Sounds like a nutrient deficiency. There are mobile and immobile nutrients in plants. The mobile ones (appears to be your issue) are able to move from older foliage to the new growth. Immoble nutrients cannot and will stay in the old leaves (new foliage will show problems). Of the common macronutrients (those that the plant uses in large supply) nitrogen, phosphorus, and potassium are mobile and in deficiency the lower foliage will die off while the plant continues to grow.
If you look closely at the leaves do you see dark pinholes in the leaves? If so do they continue to get larger? That is a typical sign of potassium deficiency. But this IMO is probably not the issue (or at least the major problem). Phosphorus is also normally not an issue with most soils
BUT in a first year hop may be somewhat of an issue because it is trying to establish a large root system. A light fertilizing of phosphorus is probably not a bad idea.
The likely cause, however, is nitrogen deficiency. It is one of the most heavily used nutrients and, more importantly, the most likely to be deficient in soil of the big 3 (as it's used up by local plants/grass/weeds). A dilute form of nitrogen would be a good measure to take ASAP in order to prevent further loss of leaves and potentially lower your hop yield. Please notice the DILUTE recommendation. Nitrogen is one nutrient that you can do more harm than good and burn the roots resulting in disease/death (just look at your neighbors yard if he over does it with the grass fertilizer).
I would probably get some general all purpose fertilizer (look for high N and high P numbers) and make up a very dilute couple of gallons. Water this in well and wait a couple of days. Pay close attention to the leaves that were just STARTING to lose color. Those are the ones that can be saved. Any that have already curled up or show damage are using up nutrients that should be going to the rest of the plant. Cut them off. Alternatively you could add some compost and water that in well, the problem being the deficiency you have seems well established and so time is of the essence.
I grow organically and so use compost exclusively, but if I saw a sudden drastic issue like you've posted, I would not hesitate to use some chemical help.
HTH