While I prefer the elimination of dedicated controls (Death to Controls?!?) I do think a physical E-Stop is prudent. Like above, I think having the E-Stop interrupt the high voltage feed makes good sense. Keep the LV stuff and controls powered so you can recover if needed. This does require two physical switches: one for main power and the E-Stop. This can be easily handled through a main contactor and contactors for elements and HV stuff (pumps, etc.). This is included in the example schematics we posted.