feinbera said:+1 for City Beer and Toronado ... the T is a bit of a dive, but you'll save a buck or two per pint. City Beer gets a bit crowded with the after-work crowd, but starts mellowing out again around 7:00.
Mikkeller just opened a bar/taproom about half a block from 5th and Market St., it's about 1/3 their stuff, 2/3 guest taps, maybe three of the 20 or so taps will you have ever tried before, definitely worth a visit.
Another long-walk/short-bus-ride option is Zeitgeist... they're also a bit divey, but with 48 taps and a giant outdoor beirgarten area, you can't beat 'em on that rare fog-free afternoon or evening.
Jupiter and Triple Rock are also good, but you will spend about 30 minutes on the train each way... make an evening of it, Triple Rock has good pub grub, and Jupiter has good pizzas and an extensive set of "guest taps" in addition to their own brews.
21st Amendment is OK... but, ultimately, pretty meh. I'd go to pretty much anything else on this thread first.
If you're feeling adventurous, Speakeasy has an awesome taproom, but you'll have to take a cab; it's way out in a light industrial area with crappy public transit access.
Enter your email address to join: