Iodine Toxicity
Chronic toxicity may develop when intake is > 1.1 mg/day. Most people who ingest excess amounts of iodine remain euthyroid. Some people who ingest excess amounts of iodine, particularly those who were previously deficient, develop hyperthyroidism (Jod-Basedow phenomenon). Paradoxically, excess uptake of iodine by the thyroid may inhibit thyroid hormone synthesis (called Wolff-Chaikoff effect). Thus, iodine toxicity can eventually cause iodide goiter, hypothyroidism, or myxedema. Very large amounts of iodide may cause a brassy taste in the mouth, increased salivation, GI irritation, and acneiform skin lesions. Patients exposed to frequent large amounts of radiographic contrast dyes or the drug amiodarone Some Trade Names
CORDARONE
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also need to have their thyroid function monitored.
Diagnosis is usually based on thyroid function and imaging test findings (see Thyroid Disorders: Laboratory Testing of Thyroid Function), which are correlated with clinical data. Iodine excretion may be more specific but is not usually measured. Treatment consists of correcting thyroid abnormalities and, if intake is excessive, dietary modification