This just came out today. If I am doing the math right, they use the phrase Heavy Beer Drinking, but are really talking about light-moderate beer drinking. 30 gms is about two 5% beers a day.
12oz x .05 ABV = .6oz EtOH
.6oz x 29.6 ml per oz = 17.8 ml EtOH per 12oz 5% ABV beer
17.8 ml x .8gm per ml = 14.25 gm EtOH per 12oz 5% ABV beer
Gastric Cancer Linked to Gene Variant, Heavy Beer Drinking
Roxanne Nelson
April 15, 2011 (Orlando, Florida) — A genetic variant might predispose heavy beer drinkers to a higher risk for gastric cancer, according to the results of a new study.
The authors found that the consumption of 60 g of pure ethanol/alcohol carried a 65% increased risk for noncardia gastric cancer. However, they note that this association was largely confined to beer.
Further analysis showed that drinking 30 g of pure ethanol/alcohol or more a day derived from beer was associated with a 75% increased risk for gastric cancer. Notably, variants in the alcohol dehydrogenase gene cluster (ADH1) greatly exacerbated the risk for gastric malignancy.
The study results were presented here at the American Association for Cancer Research 102nd Annual Meeting, and represent the first time that this association of genetic variants, beer drinking, and gastric cancer has been noted in a European population.
Inconsistent Data
Dr. Eric Duell
Alcohol consumption and the risk for gastric cancer have been evaluated in a number of epidemiologic studies, but the results have been inconsistent. There are a number of reasons for this inconsistency, said lead author Eric Duell, PhD, senior epidemiologist in the Cancer Epidemiology Research Program at the Catalan Institute of Oncology in Barcelona, Spain.
These include wide variations in beverage preferences and consumption patterns across populations, he noted during a press briefing. "Flaws in study design and methodology also might have contributed. There is also known genetic variation in alcohol metabolism within and across populations."
In their large prospective analysis, Dr. Duell and colleagues attempted to newly evaluate the association between alcohol consumption and gastric cancer.
They analyzed data from the European Prospective Investigation Into Cancer and Nutrition (EPIC), a prospective cohort of 521,000 adults 35 to 70 years of age who were recruited from 10 European countries from 1992 to 1998. The authors assessed the type and amount of alcohol consumed and associations by tumor location (cardia, noncardia), histology (diffuse, intestinal), and smoking status.
Beer Drinking Raises the Risk
In addition, they evaluated the possible effect of single-nucleotide polymorphisms (SNP) in ADH1 and its interactions with alcohol consumption in relation to gastric cancer risk in a case–control study (EurGast) nested in the EPIC cohort. Adjustment variables included age, center/country, sex, education, smoking, Helicobacter pylori infection, total energy, and dietary intake of fruits, vegetables, and red and processed meat.
The authors found that, compared with low ethanol consumption at baseline (0.1 to 4.9 g/day), heavy total consumption of alcoholic beverages (≥60 g/day) and beer (≥30 g/day) were statistically significantly associated with a higher risk for gastric cancer (total alcohol hazard ratio
12oz x .05 ABV = .6oz EtOH
.6oz x 29.6 ml per oz = 17.8 ml EtOH per 12oz 5% ABV beer
17.8 ml x .8gm per ml = 14.25 gm EtOH per 12oz 5% ABV beer
Gastric Cancer Linked to Gene Variant, Heavy Beer Drinking
Roxanne Nelson
April 15, 2011 (Orlando, Florida) — A genetic variant might predispose heavy beer drinkers to a higher risk for gastric cancer, according to the results of a new study.
The authors found that the consumption of 60 g of pure ethanol/alcohol carried a 65% increased risk for noncardia gastric cancer. However, they note that this association was largely confined to beer.
Further analysis showed that drinking 30 g of pure ethanol/alcohol or more a day derived from beer was associated with a 75% increased risk for gastric cancer. Notably, variants in the alcohol dehydrogenase gene cluster (ADH1) greatly exacerbated the risk for gastric malignancy.
The study results were presented here at the American Association for Cancer Research 102nd Annual Meeting, and represent the first time that this association of genetic variants, beer drinking, and gastric cancer has been noted in a European population.
Inconsistent Data
Dr. Eric Duell
Alcohol consumption and the risk for gastric cancer have been evaluated in a number of epidemiologic studies, but the results have been inconsistent. There are a number of reasons for this inconsistency, said lead author Eric Duell, PhD, senior epidemiologist in the Cancer Epidemiology Research Program at the Catalan Institute of Oncology in Barcelona, Spain.
These include wide variations in beverage preferences and consumption patterns across populations, he noted during a press briefing. "Flaws in study design and methodology also might have contributed. There is also known genetic variation in alcohol metabolism within and across populations."
In their large prospective analysis, Dr. Duell and colleagues attempted to newly evaluate the association between alcohol consumption and gastric cancer.
They analyzed data from the European Prospective Investigation Into Cancer and Nutrition (EPIC), a prospective cohort of 521,000 adults 35 to 70 years of age who were recruited from 10 European countries from 1992 to 1998. The authors assessed the type and amount of alcohol consumed and associations by tumor location (cardia, noncardia), histology (diffuse, intestinal), and smoking status.
Beer Drinking Raises the Risk
In addition, they evaluated the possible effect of single-nucleotide polymorphisms (SNP) in ADH1 and its interactions with alcohol consumption in relation to gastric cancer risk in a case–control study (EurGast) nested in the EPIC cohort. Adjustment variables included age, center/country, sex, education, smoking, Helicobacter pylori infection, total energy, and dietary intake of fruits, vegetables, and red and processed meat.
The authors found that, compared with low ethanol consumption at baseline (0.1 to 4.9 g/day), heavy total consumption of alcoholic beverages (≥60 g/day) and beer (≥30 g/day) were statistically significantly associated with a higher risk for gastric cancer (total alcohol hazard ratio
