The East Valley is where the brewing is at.
Four peaks is my personal favorite. Incredible beers, all well balanced, and great food. If you have time for the Sunday brunch, it's incredible.
San Tan would be my second choice, great beers, more American styles (Four peaks is more English), but the food isn't quite as good.
Sleepy Dog is relatively new, but pretty good. Nice milk stout, and a nice balanced pale ale come to mind. Cool little atmosphere, but no kitchen, although you can order food and eat it there